What are progestogens?

Progestogens are a class of natural or synthetic hormones that bind to, and activate the progesterone receptors. They produce similar effects to the natural hormone progesterone, found in the female body.  

Why are progestogens needed? 

Unopposed oestrogen replacement is associated with an increase in the risk of womb thickening (endometrial hyperplasia). This can lead to pre-cancerous changes. Taking a progestogen prevents this from happening. 

Women receiving oestrogen replacement who still have a womb (uterus), require progestogen administration for: 

• Cyclical HRT: 12-14days per cycle. 

• Continuous combined HRT regimen: on a daily basis.  

Side Effects of Progestogens? 

• Headaches 

• Gastrointestinal upset: nausea, abdominal pain 

• Breast tenderness 

• Tiredness  

If you experience any of these side-effects it may be possible to alter the form of progestogen you take, which may relieve these side effects.  

What forms do progestogen come in? 

• Tablets (separate from oestrogen) 

• Tablets (combined with oestrogen) 

• Patches (combined with oestrogen) 

• Intrauterine System- Mirena progestogen releasing coil. 

It is incredibly important that progestogens which are taken as part of a HRT regimen should not be stopped without discussion with a clinician at the practice.